Suppression of transfusion-related alloimmunization in intensively treated cancer patients
نویسندگان
چکیده
منابع مشابه
Suppression of Transfusion - Related Alloimmunization in Intensively
A retrospective review of HIA antibody testing and transfusion records of 1 00 cancer patients who required extensive platelet support revealed that 27 of 1 00 patients exhibited positive HLA antibody tests; only 13 remained positive on repetitive examination, while 88% of aplastic anemia patients so tested were positive. Sixty-five patients with leukemia, 1 6 with Ewing’s sarcoma, and 19 with ...
متن کاملSuppression of Transfusion - Related
A retrospective review of HIA antibody testing and transfusion records of 1 00 cancer patients who required extensive platelet support revealed that 27 of 1 00 patients exhibited positive HLA antibody tests; only 13 remained positive on repetitive examination, while 88% of aplastic anemia patients so tested were positive. Sixty-five patients with leukemia, 1 6 with Ewing’s sarcoma, and 19 with ...
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factor-a, which increase endothelial expression of E-selectin. These molecules tether rolling neutrophils by binding to granulocyte Lewis x sialyated carbohydrate (CD15). This allows neutrophil integrins such as complement receptor 3 (CD11b) to adhere to the endothelium via interaction with its ligand intercellular adhesion molecule-1.7 The importance of CD64 (Fc-gamma receptor I) as a marker o...
متن کاملAlloimmunization following prophylactic granulocyte transfusion.
Nineteen noninfected adults receiving initial induction chemotherapy for acute nonlymphocytic leukemia (ANLL) were randomized to receive either prophylactic granulocyte transfusion or platelet transfusion alone on an alternate-day schedule. An average of 11 granulocyte transfusions (range 3--19) were administered/patient with a mean dose of 11.5 X 10(9) granulocytes/transfusion. The groups were...
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In 1,814 patients with sickle cell disease who had been transfused, the overall rate of alloimmunization to erythrocyte antigens was 18.6%. The rate of alloimmunization in this group appears to be an explicit function of the number of transfusions received because it increases exponentially with increasing numbers of transfusions. Alloimmunization usually occurred with less than 15 transfusions...
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ژورنال
عنوان ژورنال: Blood
سال: 1981
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v58.1.122.122